Giuseppe Rengo-CNS&ND-MS
نویسندگان
چکیده
The adrenergic system has an important role in normal central nervous system function as well as in brain disease. The locus coeruleus, the main source of norepinephrine in brain, is involved in the regulation of learning and memory, reinforcement of sleep-wake cycle and synaptic plasticity. In Alzheimer’s disease, locus coeruleus degeneration is observed early in the course of the disease, years before the onset of clinical cognitive signs, with neurofibrillary detected at the stage of mild cognitive impairment, preceding amyloid deposition. Thus, in the last years, a great interest has grown in evaluating the possibility of central adrenergic system modulation as a therapeutic tool in Alzheimer’s disease. However, evidences do not show univocal results, with some studies suggesting that adrenergic stimulation might be beneficial in Alzheimer’s Disease and some others favoring adrenergic blockade. In this review, we summarize data from both hypothesis and describe the pathophysiological role of the adrenergic system in neurodegeneration.
منابع مشابه
Retraction Note: breast cancer surgery in elderly patients: postoperative complications and survival
This article [1] has been retracted by the authors due to significant overlap with a previous publication [2]. Giuseppe Rengo and Gennaro Pagano were not involved in the study and were introduced into the author list by the corresponding author. All authors, including Giuseppe Rengo and Gennaro Pagano, have subsequently agree that they did not qualify for authorship. The remaining authors apolo...
متن کاملRetraction. Breast cancer surgery in elderly patients: postoperative complications and survival.
This article [1] has been retracted by the authors due to significant overlap with a previous publication [2]. Giuseppe Rengo and Gennaro Pagano were not involved in the study and were introduced into the author list by the corresponding author. All authors, including Giuseppe Rengo and Gennaro Pagano, have subsequently agree that they did not qualify for authorship. The remaining authors apolo...
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